Functionalizing bacterial cell surfaces with a phage protein
Source: Dan Hawkes
Functionalization of bacterial cell surfaces has the potential to introduce new activities by chemical modification. ESD’s Harry Beller, Steve Singer, and others show that a bacteriophage–receptor complex can be used to functionalize the surface of two Gram-negative proteobacteria, Escherichia coli and Ralstonia eutropha with CdSe/ZnS nanoparticles. This work highlights the potential for using microbe–phage interactions to generate new functions on living cells.
Citation: Yeh, Y.-C., J. Müller, C. Bi, N.J. Hillson, H.R. Beller, S.R. Chhabra, and S.W. Singer (2013), Functionalizing bacterial cell surfaces with a phage protein. Chemical Communications, 49, 910-912.
Funding Source: BER JBI, Advanced Research Projects Agency-Energy Electrofuels Program