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Functionalizing bacterial cell surfaces with a phage protein

Source: Dan Hawkes

Functionalization of bacterial cell surfaces has the potential to introduce new activities by chemical modification. ESD’s Harry Beller, Steve Singer, and others show that a bacteriophage–receptor complex can be used to functionalize the surface of two Gram-negative proteobacteria, Escherichia coli and Ralstonia eutropha with CdSe/ZnS nanoparticles. This work highlights the potential for using microbe–phage interactions to generate new functions on living cells.

Phage_proteinFor more information, go to:

Citation: Yeh, Y.-C., J. Müller, C. Bi, N.J. Hillson, H.R. Beller, S.R. Chhabra, and S.W. Singer (2013), Functionalizing bacterial cell surfaces with a phage protein. Chemical Communications, 49, 910-912.

Funding Source: BER JBI, Advanced Research Projects Agency-Energy Electrofuels Program